Mode of Action of Nitrofurazone

Mode of action of nitrofurazone.

When Escherichia coli strain B/r is exposed to 10 to 20 mug of nitrofurazone per ml, mutants with roughly threefold resistance are obtained. Treatment of these mutants with higher concentrations of nitrofurazone yields strains with six- to seven-fold resistance over strain B/r. Each of these steps toward nitrofurazone resistance is accompanied by loss of soluble nitrofurazone reductase activity...

evolution and mode of action of pulsed radiofrequency

Mode of Action

Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...

Reproductive toxicology. Nitrofurazone.

Nitrofurazone (NF), part of a large and clinically useful class of antibacterial nitroaro-matic agents, was tested for its effects on reproduction and fertility in Swiss CD-1 mice using the RACB protocol. Data from a 2-week dose-range-finding study (Task 1) were used to set exposure concentrations for the Task 2 continuous cohabitation study at 100, 375, and 750 ppm in feed. Measures of food co...

Mode of action of tomaymycin.

The mode of action of tomaymycin (TM) which is a new antibiotic with antitumor activity was studied. Inhibition of the incorporation of labeled precursors into the acid-insoluble fraction of Bacillus subtilis cells indicated that TM inhibits nucleic acids biosynthesis, while having relatively little effect on protein synthesis. TMdisplaced methyl green (MG) from a MG-DNA complex and a TM-DNA co...